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You are here: Back issues » acp-2012 » acp-3-2012 » 04_lehmann

Imaging of the intestinal microcirculation

Christian Lehmann1, Juan Zhou1, Dragan Pavlovic2
1 Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
2 Department of Pathophysiology, American School of Medicine at Belgrade, Belgrade, Serbia and Department of Anesthesiology, Greifswald University, Greifswald, Germany
[Applied Cardiopulmonary Pathophysiology 16: 264-269, 2012]

Abstract

Microcirculatory dysfunction is important in different intestinal pathologies. Therefore, it is essential for adequate therapeutic strategies to be based on reliable microcirculatory diagnostics. Intestinal microvascular perfusion is regulated by an intricate interplay of neuroendocrine, paracrine and mechano-sensory pathways. While rectal microvascular bed can be readily examined at the patient’s bedside, microcirculation of other parts of the gut can only be assessed intra-operatively or by means of enterostomies. Changes in intestinal microcirculation in various diseases, as observed in animal experiments, further contribute to our understanding of intestinal microcirculation in humans. If  microcirculatory changes are not adequately taken care of, perfusion will be reduced and tissue oxygenation may be endangered. Relevant clinical studies are presented in this article. Future developments, e. g. miniaturization of optical probes or swallow-able cameras, will facilitate sophisticated diagnostics and thus improve treatment results.

Key words: microcirculation, intestinal, imaging, microcirculatory perfusion


Correspondence address
Dr. Christian Lehmann, MD, PhD, FRCPC
Professor, Departments of Anesthesia,
Pharmacology, Microbiology and
Immunology
Dalhousie University
5850 College Street
6H Tupper Building
Halifax, NS, B3H 1X5
Canada
Opens window for sending emailchlehmann@bitte-keinen-spamdal.ca



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