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In Silico Simulations Compared to In Vivo Measurements of the Effects of Fluid Properties on Dynamic Ventilation Parameters during Xenon Anesthesia

Ira Katz1,2, Caroline Majoral1, Christian Daviet1, Jean-Etienne Bazin3, Georges Caillibotte1
1 Medical R&D, Air Liquide Santé International, Centre de Recherche Claude-Delorme, 78354, Jouy-en-Josas, France; 2 Department of Mechanical Engineering, Lafayette College, Easton, PA, 18042, USA; 3 Service d’Anesthésie-Réanimation, CHU Estaing, 1 place Lucie Aubrac, 63003 Clermont-Ferrand
[Applied Cardiopulmonary Pathophysiology 21: 3-17, 2017]


In this paper in vivo measurements and the results of an in silico analysis of the effects of fluid property variation on dynamic ventilation parameters during xenon anesthesia are presented. The in vivo measurements of dynamic ventilatory parameters were taken prior to surgery during the wash-in phase of xenon anesthesia. The in silico model is based on a quasi-static time integration of an engineering pressure loss approach to simulate dynamic respiratory parameters during volume control mode mechanical ventiliation. The in silico model is shown to compare well with the measurements and used to directly compare the effects of fluid properties of three gas mixtures on the ventilatory parameters of peak minus plateau pressure and the maximum expiratory flow rate. Thus the use of physics based models to inform physicians of the impact of administering gas mixtures seems feasible.

Key words: lung, morphology, numerical modeling, supine, ventilator

Ira Katz
Medical R&D
Centre de Recherche Claude-Delorme
1 chemin de la Porte des Loges
Les Loges-en-Josas, B.P. 126
78354 Jouy-en-Josas Cedex
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