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Gelatine and hydroxyl ethyl starch hypervolemic hemodilution – Effect on hemorheology and retinal circulation in a pig model

M. Grossherr1, A. Hager2, T. Gerriets3, E. G. Kraatz4, M. Misfeld4, K. F. Klotz1
1Dept. of Anaesthesiology, and 4Dept. of Cardiac Surgery, University of Lübeck, Lübeck, Germany; 2Dept. of Ophthalmology, Asklepios Klinik Nord, Heidberg, Hamburg, Germany; 3Department of Neurology, Justus-Liebig-University, Gießen, Germany
[Applied Cardiopulmonary Pathophysiology 12: 40-46, 2008]

Abstract

The present study was designed to determine the effects of hemodilution with gelatine (GEL) and hydroxyethyl starch (HES) on hematocrit, blood viscosity, systemic hemodynamics, and central retinal arterial blood flow in anaesthetized pigs. 20 pigs were studied. Hypervolemic hemodilution was induced by 30 ml kg-1h-1 GEL (n=10) or HES (n=10) infused over 30 min. The hematocrit decreased comparably in both groups. Plasma viscosity was higher after HES than after GEL. Systolic central retinal blood flow and resistance index increased and were higher after HES than after GEL. Despite a greater plasma viscosity HES increases retinal microcirculation during hypervolemic hemodilution.

Key words: retinal perfusion, doppler, hydroxy ethyl starch, gelatine, plasma viscosity, hemodilution


Address for corresponding: Martin Grossherr, M.D., Department of Anaesthesiology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, E-Mail: Öffnet ein Fenster zum Versenden einer E-Mailgrossher@bitte-keinen-spamuni-luebeck.de



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